Zinc Picolinate is natural delivery from of Zinc –an essential mineral in human and animal nutrition with a wide range of biological roles. Zinc is required for a number of immune functions. Picolinic acid is produced in the pancreas and forms a complex with Zinc. This biochemical complex facilitates the passage of zinc through the gastrointestinal wall and into the circulatory system.

Thus Zinc Picolinate represents a natural and optimal delivery form of zinc, with the added advantage of greater tolerance, better absorption dynamics and greater safety.


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The Food and Nutrition Board of the Nutrition Board of the National Academy of Sciences has recommended the following Recommended Dietary Allowances (RDA) for zinc.

Age (years) RDA (milligrams/day)
0 – 1 05
1 – 10 10
Males 11 – 5+ 15
Females 11 – 51+ 12
Pregnant 15
First 6 months 19
Second 6 months 16
Picolinic acid as a delivery form of Zinc

In order for minerals in food to be utilized within the cells of the body, they must first be extracted from food, carried through the intestinal membranes, transported in the blood stream, and finally carried through the cell membrane to the interior cellular mechanisms. There are several barriers to this process. The most difficult being the intestinal wall. The cells that line the intestinal wall present a negative charge on the membrane surface. Minerals that have been dissolved in the digestive fluid which have lost their neutrality and have become positively charged will be attracted to the membrane and held tightly. In this instance, the minerals will not be allowed to pass through, and will remain held to the wall until another secretion cleanses them away. A process called chelation accomplishes this feat for some of the minerals, while for others the electrical charge attraction is as strong. Chelators are organic molecules that have their electrical charges arranged in such a way as to attract the positively charged mineral and temporarily tuck the mineral into a larger complex. Thus, with the mineral ion’s positive charge shielded by the large chelator molecule, the complex appears to be neutral or negatively charged and will not be held by the membrane as it passes through.

Picolinic acid is the body’s prime natural chelator. There is an important reason for the body to construct this molecule. It is the most efficient chelator for minerals such as chromium, zinc, manganese, copper, iron, and perhaps molybdenum.

Picolinic acid is produced from the amino acid tryptophan in the liver and kidneys, and is transported to the pancreas. During digestion, Picolinic acid is secreted from the pancreas into the intestine.

Mineral uptake by tissues is far greater when then mineral is a Picolinate, rather than the other forms. Since our bodies utilize picolinic acid to absorb and transport certain minerals, and our cells recognize mineral picolinates and readily use them, it makes sense to design mineral supplements based on this knowledge.

Role of Zinc in human nutrition

Zinc is involved in number of biologically important processes in human system

Normal growth and development: Zinc plays important roles in bone growth and mineralization and the development of reproductive organs.

Maintaining healthy skin and bones:   Zinc deficiency is linked to various skin disorders, including eczema, acne, and excessive flaking similar to what occurs in psoriasis. Hair becomes dull and lifeless looking.

Metabolic processes: Zinc is a component of various enzyme systems, and it is essential for the synthesis and metabolism of proteins and genetic material. The red blood cells also need zinc for the proper transfer of carbon dioxide.

Healing and immune function: Zinc promotes the healing of burns common infections.

Taste and smell: Zinc’s role in these senses enables a person to distinguish the taste of different foods.

Physiologically, zinc is vital for growth and developments, sexual maturation and reproduction, dark vision adaptation, olfactory and gustatory activity, insulin storage and release and for a variety of host immune defenses, among other things. Zinc deficiency can result in growth retardation, immune dysfunction, increased incidence of infections, hyypogonadism, oligospermia, anorexia, diarrhea, weight loss, delayed wound healing, neural tube defects of the fetus, increased risk for abortion, alopecia, mental lethargy and skin changes.

Zinc may have immunomodulatory activity. Zinc has putative antiviral, fertility- enhancing and retinoprotective activities.

Zinc is also very important to the newborn when breast milk may be its only source of Zinc.

Zinc is needed for the development of neutrophils and natural killer cells in the non-specific immune defense as well as acquired immunity that is attained through the activities of T-lymphocytes and B-lymphocytes.

The usefulness of Zinc to promote wound healing in the presence of low plasma zinc has been firmly established.

Use of zinc promoted the repair process of the damaged vascular tissue through stimulus of the lipoxygenase pathway that mediates response to endogenous growth factors in the healing process. Zinc compounds also hasten the healing of gastric ulcers.

It is observed that the common theme throughout research points to the fact that zinc plays an essential role in tissue healing.

Deficiency symptoms.

Even borderline zinc deficiency or disturbances in Zinc metabolism can have profound adverse health effects. Those at greatest risk of such deficiencies and disturbances include infants, children, and the elderly and pregnant women. Due to conditions that can limit the bioavailability of zinc, even when there is adequate zinc intake, zinc deficiency may affect still larger population.

Among diseases and conditions associated with zinc deficiency are alcoholism, malabsorption syndromes, acrodermatitis enteropatica, anorexia nervosa, thermal burns and total parental nutrition without zinc supplementation.

Zinc Picolinate as a nutritional supplement.

The study was a double-blind, placebo-controlled, cross-over clinical trial, and the results showed that red blood cell levels, blood serum levels, and hair levels of zinc all improved best with zinc Picolinate.

Supplement users, in fact, note that since zinc Picolinate is so well assimilated, the amount needed may be only one-third as much as normally taken for supplemental Purposes.

Zinc Picolinate is absorbed in the body to a higher degree than various other inorganic salts.

Zinc Picolinate has the greatest efficacy in reversing the zinc deficiency in acrodermatitis enteropathica, a rare genetic disorder.

Picolinic acid is a tryptophan metabolite. Patients with acrodermatitis enteropathica have a defect in the metabolism of tryptophan, which leads to picolinic acid deficiency. Zinc Picolinate helps to correct this deficiency.

Administration of zinc as zinc Picolinate is effective for patients with zinc deficiency and idiopathic taste disorder.

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