In zinc monomethionine, zinc is organically bound to a sulfur containing essential amino acid- Methionine. This provides a soluble, readily absorbable and easily retained source of Zinc.

Methionine has free radical scavenging activity by virtue of its sulfur atom, as well as its chelating ability. This anti-oxidant activity appears to account for its anti hepatotoxic activity.

Zinc monomethionine supplementation significantly increases plasma zinc levels without affecting plasma copper levels. This is important since high levels of zinc often reduce copper absorption.

It helps to strengthen immunity, enhances growth and has a major role in several basic cellular functions that are vital to the activities of immunological mediators.

Structure

Requirements

The Food and Nutrition Board of the Nutrition Board of the National Academy of Sciences has recommended the following Recommended Dietary Allowances (RDA) for zinc.

Age (years) RDA (milligrams/day)
0 – 1 05
1 – 10 10
Males 11 – 51+1 15
Females 11 – 51+1 12
Pregnant 15

Lactating

First 6 months

Second 6 months



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Significance of Methionine in human nutrition

L-Methionine is protein amino acid. It is classified as an essential amino acid for human and therefore must be supplied in the diet.

In addition to its role as a precursor in protein synthesis, L-methionine participates in a wide range of biochemical reactions, including the production of S-Adenosylmethionine (SAM or SAMe), L-cysteine, glutathione, taurine and sulfate. SAM itself, as a methyl donor, is involved in the synthesis of creatine, epinephrine, melatonin and the polyamines, spermine and spermidine, among several other substances.

Antioxidant activity of L-methionine and metabolites of L-methionine appear to account for its possible anti-hepatotoxic activity. Recent research suggests that methionine itself has free radical scavenging activity by virtue of its sulfur, as well as its chelating ability.

Role of Zinc in human nutrition

Zinc plays roles vital roles in several functions of the human system.

Normal growth and development

Zinc plays important roles in bone growth and mineralization and the development of reproductive organs.

Maintaining healthy skin and bones

Zinc deficiency is linked to various skin disorders, including eczema, acne, and excessive flaking similar to what occurs in psoriasis. Hair becomes dull and lifeless looking.

Metabolic processes

Zinc is a component of various enzyme systems, and it is essential for the synthesis and metabolism of proteins and genetic material. The red blood cells also need zinc for the proper transfer of carbon dioxide.

Healing and immune function

Zinc promotes the healing of burns common infections.

Taste and smell

Zinc’s role in these senses enables a person to distinguish the taste of different foods.


Physiologically, zinc is vital for growth and developments, sexual maturation and reproduction, dark vision adaptation, olfactory and gustatory activity, insulin storage and release and for a variety of host immune defenses, among other things.

Zinc deficiency can result in growth retardation, immune dysfunction, increased incidence of infections, hyypogonadism, oligospermia, anorexia, diarrhea, weight loss, delayed wound healing, neural tube defects of the fetus, increased risk for abortion, alopecia, mental lethargy and skin changes.

Zinc may have immunomodulatory activity. Zinc has putative antiviral, fertility- enhancing and retinoprotective activities.

Zinc is also very important to the newborn when breast milk may be its only source of Zinc.

Zinc also functions as an antioxidant as well as a membrane stabilizer. The several roles of zinc in basic cellular functions such as DNA replication, RNA transcription, cell division and activation are key to the activities of vital immunological mediators.

Zinc is needed for the development of neutrophils and natural killer cells in the non-specific immune defense as well as acquired immunity that is attained through the activities of T-lymphocytes and B-lymphocytes.

The usefulness of Zinc to promote wound healing has been firmly established.

Use of zinc promoted the repair process of the damaged vascular tissue through stimulus of the lipoxygenase pathway that mediates response to endogenous growth factors in the healing process. Zinc compounds also has the healing of gastric ulcers.

Zinc monomethionine has a nutritional supplement

Both the components of Zinc Monomethionine, Zinc and Methionine have potent antioxidant properties.

Certain in vitro studies indicate that zinc monomethionine can accentuate the biochemical consequences of oxygen free radical and it is comparable to other well-known antioxidants and free radical scavengers.

Zinc mono methionine has a triple antioxidant action - preventing and eliminating free radical formation, with methionine offering protection to the tissues against attack by free radicals.


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